Academic Commons

Articles

Genome-wide gene-based analysis of rheumatoid arthritis-associated interaction with PTPN22 and HLA-DRB1

Lo, Shaw-Hwa; Chong, Lei; Xie, Jun; Huang, Chien Hsun; Qiao, Bo; Zheng, Tian

The genes PTPN22 and HLA-DRB1 have been found by a number of studies to confer an increased risk for rheumatoid arthritis (RA), which indicates that both genes play an important role in RA etiology. It is believed that they not only have strong association with RA individually, but also interact with other related genes that have not been found to have predisposing RA mutations. In this paper, we conduct genome-wide searches for RA-associated gene-gene interactions that involve PTPN22 or HLA-DRB1 using the Genetic Analysis Workshop 16 Problem 1 data from the North American Rheumatoid Arthritis Consortium. MGC13017, HSPCAL3, MIA, PTPNS1L, and IGLVI-70, which showed association with RA in previous studies, have been confirmed in our analysis.

Subjects

Files

  • thumnail for 63e5a3dac32496ce3067c0ceecaf0c46.zip 63e5a3dac32496ce3067c0ceecaf0c46.zip binary/octet-stream 234 KB Download File
  • thumnail for 1753-6561-3-S7-S132.pdf 1753-6561-3-S7-S132.pdf binary/octet-stream 289 KB Download File
  • thumnail for 1753-6561-3-S7-S132.xml 1753-6561-3-S7-S132.xml binary/octet-stream 43 KB Download File

Also Published In

Title
BMC Proceedings

More About This Work

Academic Units
Statistics
Publisher
BioMed Central
Published Here
September 8, 2014
Academic Commons provides global access to research and scholarship produced at Columbia University, Barnard College, Teachers College, Union Theological Seminary and Jewish Theological Seminary. Academic Commons is managed by the Columbia University Libraries.