2012 Chapters (Layout Features)

Autologous Cell Therapies for Bone Tissue Regeneration

Vunjak-Novakovic, Gordana; Kregar-Velikonja, Nevenka; Krecic-Stres, Hana; Malicev, Elvira; Gantar, Danica; Krkovic, Matija; Senekovic, Vladimir; Rode, Matjaz; Knezevic, Miomir; Frohlich, Mirjam

The healing potential of bone is sufficient to restore simple fractures, which are generally treated by standard conservative or surgical therapy. However, in some cases, reparative osteogenesis does not result in structural and functional recovery of the bone. Extended bone defects following trauma or cancer resection or non-unions of fractures may require more sophisticated treatment. In these cases, bone grafting procedures, segmental bone transport, distraction osteogenesis or biomaterials are applied for reconstruction.