Cerebral Hypoxia and Ischemia in the Pathogenesis of Dementia after Stroke

Moroney, Joan T.; Bagiella, Emilia; Desmond, David W.; Paik, Myunghee C.; Stern, Yaakov; Tatemichi, Thomas K.

While it has been reported that ischemic stroke significantly increases the risk of delayed dementia,1,2 the underlying mechanisms are not well understood. Hypoxic and ischemic (HI) injury resulting from cerebral hypoperfusion due to systemic illness has been proposed as a pathogenic mechanism in certain subgroups of patients.1,3 Thus, the aim of this study was to investigate whether cerebral HI injury resulting from certain systemic illnesses (e.g., cardiac arrhythmias, cardiac failure, pneumonia, seizures, sepsis) would be an independent risk factor for the development of incident dementia after ischemic stroke.


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Annals of the New York Academy of Sciences

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February 22, 2018