Academic Commons

Articles

A comprehensive cardiopulmonary simulation model for the analysis of hypercapnic respiratory failure

Chbat, Nicolas W.; Giannessi, Massimo; Albanese, Antonio; Ursino, Mauro

We developed a new comprehensive cardiopulmonary model that takes into account the mutual interactions between the cardiovascular and the respiratory systems along with their short-term regulatory mechanisms. The model includes the heart, systemic and pulmonary circulations, lung mechanics, gas exchange and transport equations, and cardio-ventilatory control. Results show good agreement with published patient data in case of normoxic and hyperoxic hypercapnia simulations. In particular, simulations predict a moderate increase in mean systemic arterial pressure and heart rate, with almost no change in cardiac output, paralleled by a relevant increase in minute ventilation, tidal volume and respiratory rate. The model can represent a valid tool for clinical practice and medical research, providing an alternative way to experience-based clinical decisions.

Files

Also Published In

Title
EMBC 2009: Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: "Engineering the Future of Biomedicine": 2-6 September, 2009, Hilton Minneapolis, Minnesota
DOI
https://doi.org/10.1109/IEMBS.2009.5334567

More About This Work

Academic Units
Biomedical Engineering
Publisher
IEEE
Published Here
August 10, 2010
Academic Commons provides global access to research and scholarship produced at Columbia University, Barnard College, Teachers College, Union Theological Seminary and Jewish Theological Seminary. Academic Commons is managed by the Columbia University Libraries.