A comprehensive cardiopulmonary simulation model for the analysis of hypercapnic respiratory failure

Chbat, Nicolas W.; Giannessi, Massimo; Albanese, Antonio; Ursino, Mauro

We developed a new comprehensive cardiopulmonary model that takes into account the mutual interactions between the cardiovascular and the respiratory systems along with their short-term regulatory mechanisms. The model includes the heart, systemic and pulmonary circulations, lung mechanics, gas exchange and transport equations, and cardio-ventilatory control. Results show good agreement with published patient data in case of normoxic and hyperoxic hypercapnia simulations. In particular, simulations predict a moderate increase in mean systemic arterial pressure and heart rate, with almost no change in cardiac output, paralleled by a relevant increase in minute ventilation, tidal volume and respiratory rate. The model can represent a valid tool for clinical practice and medical research, providing an alternative way to experience-based clinical decisions.


Also Published In

EMBC 2009: Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: "Engineering the Future of Biomedicine": 2-6 September, 2009, Hilton Minneapolis, Minnesota

More About This Work

Academic Units
Biomedical Engineering
Published Here
August 10, 2010