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A note on QTL detecting for censored traits

Fang, Yixin

Most existing statistical methods for mapping quantitative trait loci (QTL) assume that the phenotype follows a normal distribution and that it is fully observed. However, some phenotypes have skewed distributions and may be censored. This note proposes a simple and efficient approach to QTL detecting for censored traits with the Cox PH model without estimating the baseline hazard function which is "nuisance".

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Also Published In

Title
Genetics Selection Evolution
DOI
https://doi.org/10.1186/1297-9686-38-2-221

More About This Work

Academic Units
Statistics
Publisher
BioMed Central
Published Here
September 9, 2014

Notes

QTL detecting, censored trait, interval mapping