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Lateral Membrane Waves Constitute a Universal Dynamic Pattern of Motile Cells

Dobereiner, Hans-Gunther; Dubin-Thaler, Benjamin J.; Hofman, Jake M.; Xenias, Harry S.; Sims, Tasha N.; Giannone, Gregory; Dustin, Michael L.; Wiggins, Chris H.; Sheetz, Michael P.

We have monitored active movements of the cell circumference on specifically coated substrates for a variety of cells including mouse embryonic fibroblasts and T cells, as well as wing disk cells from fruit flies. Despite having different functions and being from multiple phyla, these cell types share a common spatiotemporal pattern in their normal membrane velocity; we show that protrusion and retraction events are organized in lateral waves along the cell membrane. These wave patterns indicate both spatial and temporal long-range periodic correlations of the actomyosin gel.

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Title
Physical Review Letters
DOI
https://doi.org/10.1103/PhysRevLett.97.038102

More About This Work

Academic Units
Biological Sciences
Publisher
American Physical Society
Published Here
September 19, 2014