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Is vitamin D deficiency a risk factor for ischemic heart disease in patients with established cardiovascular disease? 10-year follow-up of the Nova Scotia Health Survey

Wasson, Lauren; Shimbo, Daichi; Rubin, Mishaela R.; Shaffer, Jonathan A.; Schwartz, Joseph E.; Davidson, Karina W.

Recent studies have reported that low serum vitamin D levels are associated with a variety of diseases, including cardiovascular disease and in particular ischemic heart disease (IHD). Possible mechanisms underlying this association include increased inflammation, reninangiotensin system upregulation, insulin resistance, altered lipid metabolism, and altered vascular smooth muscle growth and function that lead to hypertension, diabetes, dyslipidemia and atherosclerosis.[1][2] However, few longitudinal studies have explored the association between vitamin D levels and incident IHD. A nested case-control study of male health care professionals found an approximately doubled risk of incident myocardial infarction associated with lower vitamin D levels.[3] Other studies have identified trends between vitamin D levels and incident myocardial infarction but no statistically significant associations, [4][5][6] at least in part due to small sample sizes or short follow-up.

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Also Published In

Title
International Journal of Cardiology
DOI
https://doi.org/10.1016/j.ijcard.2010.12.036

More About This Work

Academic Units
Center for Behavioral Cardiovascular Health
Medicine
Publisher
Elsevier
Published Here
July 9, 2016
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