Academic Commons

Articles

Memory Awareness Influences Everyday Decision Making Capacity about Medication Management in Alzheimer's Disease

Cosentino, Stephanie; Metcalfe, Janet A.; Cary, Mark S.; De Leon, Jessica L.; Karlawish, Jason

Memory awareness in early Alzheimer’s disease (AD) influences capacity to provide informed consent for a memory treatment. This study investigated the extent to which aspects of memory awareness influence everyday decision-making capacity about medication management in AD. 42 participants with mild AD and 50 healthy elders underwent clinical ratings of memory awareness, metamemory testing, and an interview of everyday decision-making capacity regarding medication management. 45% of AD subjects were classified as aware (AAD) and 55% as unaware (UAD) based on clinical ratings and supported by metamemory testing (P = .01). Capacity was impaired in each of the AD groups as compared to the healthy elders F(2, 67) = 17.63, UAD, P less than .01; AAD, p = .01). Within the AD group, capacity correlated selectively with awareness as measured with clinical ratings (r = -.41, P = .007) but not objective metamemory testing (r = -.10, P = .60). Appreciation scores were lower in UAD as compared with AAD F(1, 35) = 8.36, P = .007. Unawareness of memory loss should heighten clinicians’ concern about everyday decision-making capacity in AD.

Files

Also Published In

Title
International Journal of Alzheimer's Disease
DOI
https://doi.org/10.4061/2011/483897

More About This Work

Academic Units
Sergievsky Center
Taub Institute
Neurology
Psychology
Published Here
September 13, 2013
Academic Commons provides global access to research and scholarship produced at Columbia University, Barnard College, Teachers College, Union Theological Seminary and Jewish Theological Seminary. Academic Commons is managed by the Columbia University Libraries.