Articles

DNA Backbone Conformation in Cis-Syn Pyrimidine[ ]Pyrimidine Cyclobutane Dimers

Broyde, Suse B.; Stellman, Steven D.; Hingerty, B.

A theoretical calculation involving minimization of energy functions was made to determine the conformation of a deoxydinucleoside monophosphate pyrimidine[ ]pyrimidine cis-syn cyclobutane dimer. Such single-stranded moieties are useful models for the in uiuo situation because single strands are more easily damaged, and the damage inhibits the normal function of single-stranded replicating DNA. The calculated minimum-energy conformer was incorporated in a mode l of B-DNA to assess the influence of this covalent lesion on the normal form of DNA.

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Also Published In

Title
Biopolymers
DOI
https://doi.org/10.1002/bip.1980.360190913

More About This Work

Academic Units
Epidemiology
Publisher
John Wiley and Sons, Inc
Published Here
June 4, 2014

Notes

Presented at the American Society of Biological Chemists and Biophysical Society Meeting, June 1-5,1980, New Orleans, Louisiana