DNA Backbone Conformation in Cis-Syn Pyrimidine[ ]Pyrimidine Cyclobutane Dimers

Broyde, Suse B.; Stellman, Steven D.; Hingerty, B.

A theoretical calculation involving minimization of energy functions was made to determine the conformation of a deoxydinucleoside monophosphate pyrimidine[ ]pyrimidine cis-syn cyclobutane dimer. Such single-stranded moieties are useful models for the in uiuo situation because single strands are more easily damaged, and the damage inhibits the normal function of single-stranded replicating DNA. The calculated minimum-energy conformer was incorporated in a mode l of B-DNA to assess the influence of this covalent lesion on the normal form of DNA.


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Academic Units
John Wiley and Sons, Inc
Published Here
June 4, 2014


Presented at the American Society of Biological Chemists and Biophysical Society Meeting, June 1-5,1980, New Orleans, Louisiana