2012 Theses Doctoral
Dynamic Digital Optical Tomography for Cancer Imaging and Therapy Monitoring
Diffuse optical tomography is a non-invasive imaging technique that uses near-infrared light to create three-dimensional images of tissue. This dissertation presents the design and validation of an instrument for rapid optical imaging using digital detection techniques. In addition to a detailed description of the instrument, three studies are presented: a clinical study detecting breast cancer using dynamic optical imaging; a pre-clinical study monitoring early tumor response to anti-angiogenic therapy; and a clinical study monitoring individual patient response to neoadjuvant chemotherapy. These studies show that diffuse optical tomography is a valuable imaging modality that can play an important role in cancer detection and treatment.
Subjects
Files
- Flexman_columbia_0054D_10618.pdf application/pdf 11.9 MB Download File
More About This Work
- Academic Units
- Biomedical Engineering
- Thesis Advisors
- Hielscher, Andreas
- Degree
- Ph.D., Columbia University
- Published Here
- March 25, 2013