Academic Commons

Theses Doctoral

Dynamic Digital Optical Tomography for Cancer Imaging and Therapy Monitoring

Flexman, Molly

Diffuse optical tomography is a non-invasive imaging technique that uses near-infrared light to create three-dimensional images of tissue. This dissertation presents the design and validation of an instrument for rapid optical imaging using digital detection techniques. In addition to a detailed description of the instrument, three studies are presented: a clinical study detecting breast cancer using dynamic optical imaging; a pre-clinical study monitoring early tumor response to anti-angiogenic therapy; and a clinical study monitoring individual patient response to neoadjuvant chemotherapy. These studies show that diffuse optical tomography is a valuable imaging modality that can play an important role in cancer detection and treatment.

Files

  • thumnail for Flexman_columbia_0054D_10618.pdf Flexman_columbia_0054D_10618.pdf application/pdf 11.9 MB Download File

More About This Work

Academic Units
Biomedical Engineering
Thesis Advisors
Hielscher, Andreas
Degree
Ph.D., Columbia University
Published Here
March 25, 2013