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TRIM5α selectively binds a restriction-sensitive retroviral capsid

Sebastian, Sarah; Luban, Jeremy

TRIM5 is a potent retrovirus inhibitor that targets viruses bearing particular capsid (CA) residues. In most primate species, retroviral restriction requires the C-terminal SPRY domain unique to the α-isoform of TRIM5, but the mechanism by which susceptible viruses are recognized and targeted for restriction is unknown. Here we show that TRIM5α binds retroviral CA from detergent-stripped virions in a SPRY-dependent manner with sufficient discrimination to account for the exquisite specificity of restriction.

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Title
Retrovirology
DOI
https://doi.org/10.1186/1742-4690-2-40

More About This Work

Academic Units
Medicine
Microbiology and Immunology
Publisher
BioMed Central
Published Here
September 9, 2014