Endocytic uptake of particles by mononuclear phagocytes and the penetration of obligate intracellular parasites

Silverstein, Samuel C.

As William Trager pointed out some time ago in a review in 'Science', all obligate intracellular parasites--be they viral, bacterial, or protozoan--face a common dilemma. That dilemma is to invade their host cells in a way that is not destructive of the host cell upon whose metabolic hospitality and functional well-being their own reproduction depends. Simply stated, these organisms must penetrate the plasma membranes of their host and take up residence in a suitable location in the cell's cytoplasm. Since many of the speakers in this session will address them selves to the issues of penetration and intracellular location of specific organisms, I view my task as one of trying to place these issues into a general conceptual framework.


Also Published In

American Journal of Tropical Medicine and Hygiene

More About This Work

Academic Units
Physiology and Cellular Biophysics
American Society of Tropical Medicine and Hygiene
Published Here
January 20, 2016