Academic Commons

Articles

Celiac disease and risk of myasthenia gravis – nationwide population-based study

Thawani, Sujata P.; Brannagan, Thomas H.; Lebwohl, Benjamin; Green, Peter H. R.; Ludvigsson, Jonas F.

Background
Case reports suggest there may be an association between celiac disease (CD) and myasthenia gravis (MG).


Methods
We identified 29,086 individuals with CD in Sweden from 1969 to 2008. We compared these individuals with 144,480 matched controls. Hazard ratios (HRs) for future MG (identified through ICD codes) were estimated using Cox regression.


Results
During 326,376 person-years of follow-up in CD patients, there were 7 MG cases (21/million person-years) compared to 22 MG cases in controls during 1,642,273 years of follow-up (14/million person-years) corresponding to a HR of 1.48 (95% CI = 0.64–3.41). HRs did not differ when stratifying for age, sex or calendar period. HRs were highest in the first year after follow-up, though insignificant. Individuals with CD were at no increased risk of MG more than 5 years after CD diagnosis (HR = 0.70; 95% CI = 0.16–3.09).


Conclusion
This study found no increased risk of MG in patients with CD.

Files

  • thumnail for 12883_2018_Article_1035.pdf 12883_2018_Article_1035.pdf application/pdf 377 KB Download File

Also Published In

More About This Work

Academic Units
Neurology
Medicine
Published Here
March 30, 2018

Notes

Autoimmune, Celiac, Gluten, Myasthenia gravis

Academic Commons provides global access to research and scholarship produced at Columbia University, Barnard College, Teachers College, Union Theological Seminary and Jewish Theological Seminary. Academic Commons is managed by the Columbia University Libraries.