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Isolated Chorea Associated with LGI1 Antibody

Ramdhani, Ritesh A.; Frucht, Steven J.

Background
Leucine-rich glioma inactivated 1 (LGI1) antibody produces a syndrome of limbic encephalitis, hyponatremia, and facio-brachial dystonic seizures that is non-paraneoplastic and responsive to corticosteroids. Parkinsonism, tremor, and generalized chorea are rare manifestations of LGI1, but, when present, commonly accompany other signs of limbic encephalitis.

Case Report
We present a case of LGI1-related isolated chorea in a 53-year-old Japanese male. His chorea responded to high-dose steroids, suggesting a potential role for this synaptic antibody in triggering chorea.

Discussion
This case highlights a new treatable etiology of chorea.

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Title
Tremor and Other Hyperkinetic Movements
DOI
https://doi.org/10.7916/D8MG7MFC

More About This Work

Academic Units
Center for Parkinson's Disease and Other Movement Disorders
Published Here
February 7, 2014