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Microgravity Studies of Cells and Tissues: from Mir to ISS

Vunjak-Novakovic, Gordana; Preda, Carmen; Bordonaro, Julie; Pellis, Neal; de Luis, Javier; Freed, Lisa E.

In vitro studies of cells and tissues in microgravity, either simulated by cultivation conditions on earth or reduced by spaceflight, are essential for the identification of mechanisms underlying gravity sensing and transduction in biological organisms. In this paper, we review rotating bioreactor studies of engineered skeletal and cardiovascular tissues carried out in unit gravity, a Shuttle-Mir study of cartilage tissue engineering, and the ongoing development and testing of a Cell Culture Unit for cell and tissue cultivation aboard the ISS.

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Title
AIP Conference Proceedings
DOI
https://doi.org/10.1063/1.57609

More About This Work

Academic Units
Biomedical Engineering
Publisher
American Institute of Physics
Published Here
January 23, 2014