1985 Articles

Nucleolar organizer regions in patients with precancerous and cancerous lesions of the uterine cervix

Vundavalli, Murty V.; Mitra, A. B.; Sharma, J. K.; Luthra, U. K.

Nucleolar organizer regions (Ag-NORs) were studied in patients with cervical precancerous and cancerous lesions along with controls. The data revealed a statistically significant decrease of Ag-NORs in cancer patients, as well as in women with severe precancerous lesions as compared with controls. A similar decrease in the amount of Ag-staining was also observed in both cancer and severe dysplasia cases. The study suggests a possible relationship of Ag-NOR activity to malignancy.