2013 Articles
The Kinase PDK1 Is Essential for B-Cell Receptor Mediated Survival Signaling
Phosphoinositide-dependent kinase 1 (PDK1) plays an important role in integrating the T cell antigen receptor (TCR) and CD28 signals to achieve efficient NF-κB activation. PDK1 is also an important regulator of T cell development, mediating pre-TCR induced proliferation signals. However, the role of PDK1 in B cell antigen receptor (BCR) signaling and B cell development remains largely unknown. In this study we provide genetic evidence supporting the role of PDK1 in B cell survival. We found PDK1 is required for BCR mediated survival in resting B cells, likely through regulation of Foxo activation. PDK1-dependent signaling to NF-κB is not crucial to resting B cell viability. However, PDK1 is necessary for triggering NF-κB during B cell activation and is required for activated B cell survival. Together these studies demonstrate that PDK1 is essential for BCR-induced signal transduction to Foxo and NF-κB and is indispensable for both resting and activated B cell survival.
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- journal.pone.0055378.PDF application/pdf 2.53 MB Download File
Also Published In
- Title
- PLOS ONE
- DOI
- https://doi.org/10.1371/journal.pone.0055378
More About This Work
- Academic Units
- Microbiology and Immunology
- Published Here
- June 21, 2017