fMRI Evidence of Compensatory Mechanisms in Older Adults at Genetic Risk for Alzheimer Disease [Response]

Scarmeas, Nikolaos; Stern, Yaakov

We read the recent article by Bondi et al. with great interest. The authors review previous studies suggesting that blood oxygenation level dependent (BOLD) brain responses during performance of memory tasks are of greater magnitude and more diffuse in patients with early Alzheimer disease (AD) than in normal older individuals. They also review previous studies demonstrating an increase in the intensity and extent of brain activation for non-demented E4 carriers.



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June 6, 2018