Academic Commons

Articles

White Matter Microstructure in Idiopathic Craniocervical Dystonia

Pinheiro, Giordanna L. S.; Guimarães, Rachel P.; Piovesana, Luiza G.; Campos, Brunno M.; Campos, Lidiane S.; Azevedo, Paula C.; Torres, Fabio R.; Amato‐Filho, Augusto C.; França Jr, Marcondes C.; Lopes‐Cendes, Iscia; Cendes, Fernando; D’Abreu, Anelyssa

Background: Dystonias are hyperkinetic movement disorders characterized by involuntary muscle contractions resulting in abnormal torsional movements and postures. Recent neuroimaging studies in idiopathic craniocervical dystonia (CCD) have uncovered the involvement of multiple areas, including cortical ones. Our goal was to evaluate white matter (WM) microstructure in subjects with CCD using diffusion tensor imaging (DTI) analysis.
Methods: We compared 40 patients with 40 healthy controls. Patients were then divided into subgroups: cervical dystonia, blepharospasm, blepharospasm + oromandibular dystonia, blepharospasm + oromandibular dystonia + cervical dystonia, using tract‐based spatial statistics. We performed a region of interest‐based analysis and tractography as confirmatory tests.
Results: There was no significant difference in the mean fractional anisotropy (FA) and mean diffusivity (MD) between the groups in any analysis.
Discussion: The lack of DTI changes in CCD suggests that the WM tracts are not primarily affected.

Files

Also Published In

Title
Tremor and Other Hyperkinetic Movements
DOI
https://doi.org/10.7916/D86972H6

More About This Work

Academic Units
Center for Parkinson's Disease and Other Movement Disorders
Published Here
October 14, 2015
Academic Commons provides global access to research and scholarship produced at Columbia University, Barnard College, Teachers College, Union Theological Seminary and Jewish Theological Seminary. Academic Commons is managed by the Columbia University Libraries.