APOE Genotype and Cerebral Blood Flow in Healthy Young Individuals

Scarmeas, Nikolaos; Habeck, Christian G.; Stern, Yaakov; Anderson, Karen E.

To the Editor: Several epidemiologic studies have found an association between the presence of an apolipoprotein E (APOE) ∊4 allele and increased risk for Alzheimer disease (AD). Although 2 brain imaging studies of middle-aged and elderly individuals have found that the ∊4 allele is associated with an AD-like pattern on positron emission tomogrophy (PET) brain scans,1,2 we are not aware of any study has that has examined this association in young individuals.


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Journal of the American Medical Association

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February 22, 2018