Academic Commons

Articles

Relationship between premature ventricular complexes and depressive symptoms in non-ST-elevation acute coronary syndrome

Whang, William; Peacock, James; Soto, Ana V.; Borda, Tomas; Bhatt, Anupama; Richardson, Safiya; Burg, Matthew M.; Davidson, Karina W.

Aims: Depression is a recognized risk marker for mortality among acute coronary syndrome (ACS) patients. We hypothesized that ventricular arrhythmia detected by inpatient telemetry monitoring is more frequent among ACS patients with elevated depressive symptoms compared to those without depressive symptoms.
Methods and results: We analysed data from patients enrolled in a prospective observational study of depression in ACS. Telemetry recordings during the index admission (average recording 21.3±3.0 hours) were analysed for frequent premature ventricular complexes (PVCs), defined as ≥10 per hour. The self-report Beck Depression Inventory (BDI) was used to assess depressive symptoms. Among 200 ACS patients, frequent PVCs were observed in 29% of patients with moderate depressive symptoms (BDI ≥10), 27% of those with mild symptoms (BDI 5–9), and only 11% of those with no/minimal symptoms (p=0.02). Log-transformed PVCs per hour were associated with depressive symptom category (p=0.008). In a multivariable logistic regression model that included age, gender, left ventricular ejection fraction, cardiovascular risk score, heart rate, and QT interval, mild symptoms (OR 3.02, 95% 0.97–9.43, p=0.058) and moderate-severe symptoms (OR 3.94, 95% CI 1.27–12.22, p=0.018) were associated with frequent PVCs.
Conclusions: In this sample of ACS patients, depressive symptoms were independently associated with frequent PVCs during inpatient telemetry monitoring.

Files

  • thumnail for Whang_Eur_Heart_J_2013.pdf Whang_Eur_Heart_J_2013.pdf application/pdf 836 KB Download File

Also Published In

Title
European Heart Journal: Acute Cardiovascular Care
DOI
https://doi.org/10.1177/2048872613476101

More About This Work

Academic Units
Center for Behavioral Cardiovascular Health
Medicine
Publisher
SAGE Publications
Published Here
May 17, 2016
Academic Commons provides global access to research and scholarship produced at Columbia University, Barnard College, Teachers College, Union Theological Seminary and Jewish Theological Seminary. Academic Commons is managed by the Columbia University Libraries.