2007 Articles
Leisure Activity and Cognitive Decline in Incident Alzheimer Disease
Background: High rates of leisure activity have been associated with reduced risk of Alzheimer disease (AD). Objective: To determine whether prediagnosis leisure activity modifies the rate of cognitive decline in patients with AD. Design: Inception cohort followed up longitudinally for a mean of 5.3 years (up to 13.9 years). Setting: Urban community. Participants: A total of 283 patients with incident AD (mean age, 79 years; 56.2% Hispanic and 31.1% African American). Main Outcome Measures: Change in a composite cognitive score from diagnosis on and during the entire study follow-up. Results: In multivariate-adjusted generalized estimating equation models of postdiagnosis change (n = 133), each leisure activity was associated with an additional yearly decline of 0.005 of a z-score unit in cognitive score (P = .17). In models expanded to include cognitive change during study follow-up, including evaluations before and after diagnosis (n = 283), each activity was associated with an additional yearly decline of 0.005 of a z-score unit in cognitive score (P = .03). The association was strongest for intellectual activities. Conclusions: Greater participation in prediagnosis leisure activities, especially intellectual activities, was associated with faster cognitive decline, supporting the hypothesis that the disease course in AD may vary as a function of cognitive reserve.
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Also Published In
- Title
- JAMA Neurology
- DOI
- https://doi.org/10.1001/archneur.64.12.1749
More About This Work
- Academic Units
- Taub Institute
- Publisher
- American Medical Association
- Published Here
- January 28, 2016