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Transcription factors in normal and malignant cells

Herrlich, Peter; Ponta, Helmut; Stein, Bernd; Jonat, Carsten; Gebel, Stephan; König, Harald; Williams, Richard O.; Ivanov, Vladimir N.; Rahmsdorf, Hans J.

Normal cells and cancer cells differ in the obvious features of cellular phenotype, e.g. in various degrees of escape from normal growth control mechanisms and of invasiveness. These massive changes in phenotype are based on an altered program of expressed genes. Although cancer cells constantly alter their properties, i.e. they progress, portions of the altered program are stable over many cell generations or even established permanently, probably because of selective pressure. Genes affected in the altered program code for growth factor receptors and growth factors, for components of or enzymes acting at the extracellular matrix and for various intracellular and membrane-bound proteins. It is reasonable to assume that the alterations of the genetic program are related to the mutations and gene rearrangements that make up the cancer cell. Advances in two separate areas of research, the process of carcinogenesis and the mechanisms of gene regulation, permit suggestions about the molecular links between carcinogenic mutation and gene expression, as well as suggestions for their experimental verification.


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Molecular biology of cancer genes
Ellis Horwood

More About This Work

Academic Units
Center for Radiological Research
Ellis Horwood series in molecular biology
Published Here
April 25, 2016