Academic Commons

Articles

Directionality of the Relationship Between Depressive Symptom Dimensions and C-Reactive Protein in Patients With Acute Coronary Syndromes

Shaffer, Jonathan A.; Edmondson, Donald E.; Chaplin, William F.; Schwartz, Joseph E.; Shimbo, Daichi; Burg, Matthew M.; Rieckmann, Nina; Davidson, Karina W.

Objective: Previous theoretical models predict that elevated inflammation may predict later depressive symptoms, but bidirectional associations are possible. We examined whether depressive symptoms or inflammation predicts change in the other for a 3-month period in a sample of adults with acute coronary syndromes (ACS). Methods: During hospitalization for their index ACS event (baseline) and then again 1 and 3 months later, 163 post-ACS patients completed the Beck Depression Inventory, a measure of depressive symptom severity with cognitive-affective and somatic-affective subscales. C-reactive protein (CRP) was also assessed at each visit; known correlates of depression and CRP were assessed at baseline. Path analyses were conducted to evaluate prospective associations between depressive symptoms and log-transformed CRP values and whether strength and/or directionality varied by specific depressive symptom dimensions. Results: Baseline total depressive symptom severity predicted a smaller decrease in CRP from baseline to 1 month (unstandardized parameter estimates [B] = 0.04, p < .001) controlling for all covariates, as did baseline cognitive-affective depressive symptom severity (B = 0.10, p = .02). Baseline somatic-affective depressive symptom severity did not predict change in CRP (B = −0.002, p = .94). CRP did not predict 1- or 3-month change in total, cognitive-affective, or somatic-affective depressive symptom severity. The results did not differ for men and women. Conclusions: Greater cognitive-affective and total depressive symptom severity at the time of a cardiac event predicts a smaller decrease in CRP 1 month later, but there was no evidence in this study that CRP predicts change in depressive symptoms.

Files

  • thumnail for Shaffer_Psychosom_Med_2011_PMC.pdf Shaffer_Psychosom_Med_2011_PMC.pdf application/download 356 KB Download File

Also Published In

Title
Psychosomatic Medicine
DOI
https://doi.org/10.1097/PSY.0b013e31821deafd

More About This Work

Academic Units
Center for Behavioral Cardiovascular Health
Publisher
American Psychosomatic Society
Published Here
April 17, 2016