Academic Commons

Articles

Ambient Metals, Elemental Carbon, and Wheeze and Cough in New York City Children through 24 Months of Age

Patel, Molini M.; Hoepner, Lori A.; Garfinkel, Robin S.; Chillrud, Steven N.; Reyes, Andria; Quinn, James; Perera, Frederica P.; Miller, Rachel L.

Rationale: The effects of exposure to specific components of ambient fine particulate matter (PM2.5), including metals and elemental carbon (EC), have not been fully characterized in young children.

Objectives: To compare temporal associations among PM2.5; individual metal constituents of ambient PM2.5, including nickel (Ni), vanadium (V), and zinc (Zn); and EC and longitudinal reports of respiratory symptoms through 24 months of age.

Methods: Study participants were selected from the Columbia Center for Children's Environmental Health birth cohort recruited in New York City between 1998 and 2006. Respiratory symptom data were collected by questionnaire every 3 months through 24 months of age. Ambient pollutant data were obtained from state-operated stationary monitoring sites located within the study area. For each subject, 3-month average inverse-distance weighted concentrations of Ni, V, Zn, EC, and PM2.5 were calculated for each symptom-reporting period based on the questionnaire date and the preceding 3 months. Associations between pollutants and symptoms were characterized using generalized additive mixed effects models, adjusting for sex, ethnicity, environmental tobacco smoke exposure, and calendar time.

Measurements and Main Results: Increases in ambient Ni and V concentrations were associated significantly with increased probability of wheeze. Increases in EC were associated significantly with cough during the cold/flu season. Total PM2.5 was not associated with wheeze or cough.

Conclusions: These results suggest that exposure to ambient metals and EC from heating oil and/or traffic at levels characteristic of urban environments may be associated with respiratory symptoms among very young children.

Geographic Areas

Files

Also Published In

Title
American Journal of Respiratory and Critical Care Medicine
DOI
https://doi.org/10.1164/rccm.200901-0122OC

More About This Work

Academic Units
Environmental Health Sciences
Epidemiology
Irving Comprehensive Cancer Center
Lamont-Doherty Earth Observatory
Medicine
Publisher
American Thoracic Society
Published Here
April 20, 2016
Academic Commons provides global access to research and scholarship produced at Columbia University, Barnard College, Teachers College, Union Theological Seminary and Jewish Theological Seminary. Academic Commons is managed by the Columbia University Libraries.