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Detecting transcriptionally active regions using genomic tiling arrays

Halasz, Gabor; van Batenburg, Marinus F.; Perusse, Joelle; Hua, Sujun; Lu, Xiang-Jun; White, Kevin P.; Bussemaker, Harmen J.

We have developed a method for interpreting genomic tiling array data, implemented as the program TranscriptionDetector. Probed loci expressed above background are identified by combining replicates in a way that makes minimal assumptions about the data. We performed medium-resolution Anopheles gambiae tiling array experiments and found extensive transcription of both coding and non-coding regions. Our method also showed improved detection of transcriptional units when applied to high-density tiling array data for ten human chromosomes.

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Title
Genome Biology
DOI
https://doi.org/10.1186/gb-2006-7-7-r59

More About This Work

Academic Units
Biological Sciences
Center for Computational Biology and Bioinformatics
Published Here
September 9, 2014