Higher blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentrations correlate with lower olfactory scores in essential tremor

Louis, Elan D.; Rios, Eileen; Pellegrino, Kathryn M.; Jiang, Wendy; Factor-Litvak, Pam; Zheng, Wei

Harmane (1-methyl-9H-pyrido[3,4-b]indole), a neurotoxin, may be an environmental risk factor for essential tremor (ET). Harmane and related chemicals are toxic to the cerebellum. Whether it is through this mechanism (cerebellar toxicity) that harmane leads to ET is unknown. Impaired olfaction may be a feature of cerebellar disease.



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Center for Parkinson's Disease and Other Movement Disorders
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August 30, 2012