2010 Articles
Notch regulates the angiogenic response via induction of VEGFR-1
Notch is a critical regulator of angiogenesis and arterial specification. We show that ectopic expression of activated Notch1 induces endothelial morphogenesis in human umbilical vein endothelial cells (HUVEC) in a VEGFR-1-dependent manner. Notch1-mediated upregulation of VEGFR-1 in HUVEC increased their responsiveness to the VEGFR-1 specific ligand, Placental Growth Factor (PlGF). In mice and human endothelial cells, inhibition of Notch signaling resulted in decreased VEGFR-1 expression during VEGF-A-induced neovascularization. In summary, we show that Notch1 plays a role in endothelial cells by regulating VEGFR-1, a function that may be important for physiological and pathological angiogenesis.
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Also Published In
- Title
- Journal of Angiogenesis Research
- DOI
- https://doi.org/10.1186/2040-2384-2-3
More About This Work
- Academic Units
- Obstetrics and Gynecology
- Publisher
- BioMed Central
- Published Here
- September 8, 2014