Hypermetabolism of Olivary Nuclei in a Patient with Progressive Ataxia and Palatal Tremor

Korpela, Jaana; Joutsa, Juho; Rinne, Juha O.; Bergman, Jörgen; Kaasinen, Valtteri

Background: The pathophysiology of the movement disorder progressive ataxia with palatal tremor (PAPT) is unclear.

Case report: A 77-year-old male presented with dysarthria, ataxia, and 1–2 Hz palatal tremor. A diagnosis of probable sporadic PAPT was established. Brain magnetic resonance imaging was normal at the presymptomatic phase but later showed olivary hypertrophy. Brain [18F]-fludeoxyglucose (FDG) positron emission tomography (PET) showed bilateral hypermetabolism in the olivary nuclei.

Discussion: This second reported patient with PAPT and FDG-PET shows that olivary hypertrophy is paralleled with hypermetabolism. The olivary nuclei pathology also appears to be temporally associated with symptom onset.


Also Published In

Tremor and Other Hyperkinetic Movements

More About This Work

Academic Units
Center for Parkinson's Disease and Other Movement Disorders
Published Here
October 15, 2015