Academic Commons

Articles

Altered glucose disposition and insulin sensitivity in peri-pubertal first-degree relatives of women with polycystic ovary syndrome

Raissouni, Nouhad; Kolesnikov, Andrey; Purushothaman, Radhika; Sinha, Sunil; Bhandari, Sonal; Bhangoo, Amrit; Malik, Shahid; Mathew, Revi; Baillargeon, Jean-Patrice; Hernandez, Maria; Rosenbaum, Michael; Ten, Svetlana; Geller, David

Background: First-degree relatives (FDRs) of women with PCOS are at increased risk for impaired insulin sensitivity and diabetes mellitus. Glucose tolerant FDR have evidence of insulin resistance and hyperinsulinemia prior to emergence of frank PCOS. Aim: To study insulin dynamics parameters in the early adolescent FDR of women with PCOS. Methods: This is a cross-sectional study involving 18 adolescents whose mothers or sisters had been diagnosed with PCOS and 21 healthy, age-matched control adolescents without FDR. Subjects underwent anthropometric measurements, steroid profiling and frequently sampled Intravenous Glucose Tolerance Test (IVGTT), Homeostasis Model Assessment (HOMA) index, Glucose Disposal Index (GDI), Acute Insulin Response (AIR) and Quantitative insulin sensitivity check index (QUICKI) were derived from IVGTT results. Results: FDRs showed significantly higher mean HOMA and lower GDI. There were no differences in mean age or BMI Z-score between the cohorts. No differences in sex steroids or AIR were identified between groups. Conclusion: Female adolescent FDR of women with PCOS have higher HOMA index and lower QUICKI, reflecting altered insulin sensitivity and lower GDI reflecting poorer beta-cell function. The presence of multiple risk factors for type 2 diabetes suggests that aggressive screening of the early adolescent FDR of women with PCOS is indicated.

Files

  • thumnail for 1687-9856-2012-14.xml 1687-9856-2012-14.xml binary/octet-stream 51.2 KB Download File

Also Published In

Title
International Journal of Pediatric Endocrinology
DOI
https://doi.org/10.1186/1687-9856-2012-14

More About This Work

Academic Units
Pediatrics
Publisher
BioMed Central
Published Here
September 9, 2014

Notes

PCOS, Insulin resistance, Insulin sensitivity, Anovulation, Hyperandrogenemia, Premature pubarche, Diabetes mellitus, Beta cell function

Academic Commons provides global access to research and scholarship produced at Columbia University, Barnard College, Teachers College, Union Theological Seminary and Jewish Theological Seminary. Academic Commons is managed by the Columbia University Libraries.