Intracellular calcium release channels: an update

Santulli, Gaetano; Nakashima, Ryutaro; Yuan, Qi; Marks, Andrew R.

Ryanodine receptors (RyRs) and inositol 1,4,5-trisphosphate receptors (IP3Rs) are calcium (Ca2+) release channels on the endo/sarcoplasmic reticulum (ER/SR). Here we summarize the latest advances in the field, describing the recently discovered mechanistic roles of intracellular Ca2+ release channels in the regulation of mitochondrial fitness and endothelial function, providing novel therapeutic options for the treatment of heart failure, hypertension, and diabetes mellitus.


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Also Published In

The Journal of Physiology

More About This Work

Academic Units
Physiology and Cellular Biophysics
Published Here
March 27, 2017