Academic Commons

Articles

Double-minute chromosomes in the leukocytes of a patient with a previous history of cervical carcinoma

Mitra, A. B.; Vundavalli, Murty V.; Luthra, Usha K.

Double-minute chromosomes (DMs) were observed in repeated samples in the leukocytes of a patient with a previous history of cervical carcinoma. The most interesting cytogenetic finding was the coexistence of DMs and a dicentric chromosome along with chromosome- and chromatid-type breaks and gaps. This observation suggests that DMs might originate through the breakage of existing chromosomes. The presence of DMs in leukocytes may also indicate the possibility that certain common agents cause DMs in tumor cells as well as in normal cells.

Files

  • thumnail for Mitra_AB_et_al_Cancer_Genet_Cytogenet_1983.pdf Mitra_AB_et_al_Cancer_Genet_Cytogenet_1983.pdf application/pdf 308 KB Download File

Also Published In

Title
Cancer Genetics and Cytogenetics
DOI
https://doi.org/10.1016/0165-4608(83)90043-2

More About This Work

Academic Units
Pathology and Cell Biology
Published Here
January 11, 2017