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CRISPR-mediated genome editing of Plasmodium falciparum malaria parasites

Lee, Marcus C. S.; Fidock, David Armand

The development of the CRISPR-Cas system is revolutionizing genome editing in a variety of organisms. The system has now been used to manipulate the genome of Plasmodium falciparum, the most lethal malaria-causing species. The ability to generate gene deletions or nucleotide substitutions rapidly and economically promises to accelerate the analysis of novel drug targets and to help elucidate the function of specific genes or gene families, while complementing genome-wide association studies.

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Also Published In

Title
Genome Medicine
DOI
https://doi.org/10.1186/s13073-014-0063-9

More About This Work

Academic Units
Microbiology and Immunology
Published Here
September 10, 2015