Angiogenesis and Ovarian Function

Douglas, Nataki C.; Nakhuda, Gary S.; Sauer, Mark V.; Zimmermann, Ralf C.

Ovarian follicle development and corpus luteum formation involves recurrent, regulated, and self-limited angiogenesis. In rodent and non-human primate models it was shown that the VEGF/VEGF receptor 2 signal transduction pathway is of critical importance for ovarian angiogenesis. Clinically manipulation of this pathway might be helpful in finding new treatment methods for ovarian cancer, ovarian hyperstimulation syndrome, polycystic ovarian disease, endometriosis, as well as new, non-hormonal contraceptive approaches.


Also Published In

Journal für Fertilität und Reproduktion

More About This Work

Academic Units
Obstetrics and Gynecology
Published Here
August 20, 2012