Academic Commons

Articles

Greater hippocampal volume is associated with PTSD treatment response

Rubin, Mikael; Shvil, Erel; Papini, Santiago; Chhetry, Binod T.; Helpman, Liat; Markowitz, John C.; Mann, J. John; Neria, Yuval

Previous research associates smaller hippocampal volume with posttraumatic stress disorder (PTSD). It is unclear, however, whether treatment affects hippocampal volume or vice versa. Seventy-six subjects, 40 PTSD patients and 36 matched trauma-exposed healthy resilient controls, underwent clinical assessments and magnetic resonance imaging (MRI) at baseline, and 10 weeks later, during which PTSD patients completed ten weeks of Prolonged Exposure (PE) treatment. The resilient controls and treatment responders (n=23) had greater baseline hippocampal volume than treatment non-responders (n=17) (p=0.012 and p=0.050, respectively), perhaps due to more robust fear-extinction capacity in both the initial phase after exposure to trauma and during treatment.

Files

  • thumnail for Rubin_et_al.__Hippocampus_and_PTSD__2016.pdf Rubin_et_al.__Hippocampus_and_PTSD__2016.pdf text/pdf 221 KB Download File

Also Published In

Title
Psychiatry Research: Neuroimaging
DOI
https://doi.org/10.1016/j.pscychresns.2016.05.001

More About This Work

Academic Units
Epidemiology
Psychiatry
Radiology
Publisher
Elsevier
Published Here
August 12, 2016
Academic Commons provides global access to research and scholarship produced at Columbia University, Barnard College, Teachers College, Union Theological Seminary and Jewish Theological Seminary. Academic Commons is managed by the Columbia University Libraries.