Methodological Issues in Clinical Drug Development for Essential Tremor

Carranza, Michael A.; Snyder, Madeline R.; Elble, Rodger J.; Boutzoukas, Angelique E.; Zesiewicz, Theresa A.

Essential tremor (ET) is one of the most common tremor disorders in the world. Despite this, only two medications have received Level A recommendations from the American Academy of Neurology to treat it (primidone and propranolol). Even though these medications provide relief to a large group of ET patients, up to 50% of patients are non-responders. Additional medications to treat ET are needed. This review discusses some of the methodological issues that should be addressed for quality clinical drug development in ET.



Also Published In

Tremor and Other Hyperkinetic Movements

More About This Work

Academic Units
Center for Parkinson's Disease and Other Movement Disorders
Published Here
August 21, 2012