Purkinje cell axonal torpedoes are unrelated to advanced aging and likely reflect cerebellar injury

Louis, Elan D.; Faust, Phyllis L.; Vonsattel, Jean Paul; Erickson-Davis, Cordelia

Torpedoes, swellings of the proximal Purkinje cell axon, are thought to represent a cellular response to injury [3]. They may occur in a variety of cerebellar disorders [7]. Most recently, their numbers were noted to be six-times higher in essential tremor (ET) than control brains [4]. Torpedoes are also often viewed as a cumulative phenomenon associated with advanced aging [3,4], yet there are surprisingly few supporting data. We quantified torpedoes in normal human cerebella spanning a considerable age range to assess whether torpedoes are a cumulative phenomenon of aging. These data help place the relative abundance of torpedoes in ET in context.



Also Published In

Acta Neuropathologica

More About This Work

Academic Units
Center for Parkinson's Disease and Other Movement Disorders
Published Here
July 30, 2012