Quantitative validation of optical flow based myocardial strain measures using sonomicrometry

Duan, Qi; Parker, Katherine M.; Lorsakul, Auranuch; Angelini, Elsa D.; Hyodo, Eiichi; Homma, Shunichi; Holmes, Jeffrey W.; Laine, Andrew F.

Dynamic cardiac metrics, including myocardial strains and displacements, provide a quantitative approach to evaluate cardiac function. However, in current clinical diagnosis, largely 2D strain measures are used despite that cardiac motions are complex 3D volumes over time. Recent advances in 4D ultrasound enable the capability to capture such complex motion in a single image data set. In our previous work, a 4D optical flow based motion tracking algorithm was developed to extract full 4D dynamic cardiac metrics from such 4D ultrasound data. In order to quantitatively evaluate this tracking method, in-vivo coronary artery occlusion experiments at various locations were performed on three canine hearts. Each dog was screened with 4D ultrasound and sonomicrometry data was acquired during each occlusion study. The 4D ultrasound data from these experiments was then analyzed with the tracking method and estimated principal strain measures were directly compared to those recorded by sonomicrometry. Strong agreement was observed independently for the three canine hearts. This is the first validation study of optical flow based strain estimation for 4D ultrasound with a direct comparison with sonomicrometry using in-vivo data.


Also Published In

2009 6th IEEE International Symposium on Biomedical Imaging: From Nano to Macro: Proceedings: June 28-July 1, 2009, Boston Park Plaza Hotel, Boston, Massachusetts, U.S.A.

More About This Work

Academic Units
Biomedical Engineering
Published Here
August 10, 2010