Academic Commons


Plasma sphingomyelin and longitudinal change in percent emphysema on CT. The MESA Lung study

Ahmed, Firas S.; Jiang, Xian-cheng; Schwartz, Joseph E.; Hoffman, Eric A.; Yeboah, Joseph; Shea, Steven J. C.; Burkart, Kristin Marie; Barr, R. Graham

Context: Ceramide causes endothelial apoptosis and emphysema-like changes in animal models.

Objectives: Test if plasma sphingomyelin, a major precursor of ceramide, would predict longitudinal increase in the percentage of emphysema-like lung on computed tomography (CT).

Materials and methods: 3840 participants had their plasma sphingomyelin measured at baseline examination and their pulmonary emphysema measured on cardiac CT scans at baseline and on follow-up visits. Mixed effects models were used to adjust for potential confounders.

Results: One standard deviation increase in sphingomyelin predicted a 0.12% per year (95% CI: 0.02–0.22; p = 0.019) greater increase of percent emphysema.

Discussion and conclusion: Higher plasma levels of sphingomyelin predicted greater annual increase in quantitatively measured percent emphysema.


  • thumnail for Ahmed_Biomarkers_2014_PMC.pdf Ahmed_Biomarkers_2014_PMC.pdf application/pdf 222 KB Download File

Also Published In

More About This Work

Academic Units
Center for Behavioral Cardiovascular Health
Taylor & Francis
Published Here
September 12, 2016
Academic Commons provides global access to research and scholarship produced at Columbia University, Barnard College, Teachers College, Union Theological Seminary and Jewish Theological Seminary. Academic Commons is managed by the Columbia University Libraries.