Articles

Toward a biomarker panel measured in CNS-originating extracellular vesicles for improved differential diagnosis of Parkinson’s disease and multiple system atrophy

Taha, Hash B.; Hornung, Simon; Dutta, Suman; Fenwick, Leony; Lahgui, Otmane; Howe, Kathryn; Elabed, Nour; del Rosario, Irish; Wong, Darice Y.; Duarte Folle, Aline; Markovic, Daniela; Palma, Jose-Alberto; Kang, Un J.; Alcalay, Roy N.; Sklerov, Miriam; Kaufmann, Horacio; Fogel, Brent L.; Bronstein, Jeff M.; Ritz, Beate; Bitan, Gal

Synucleinopathies are neurodegenerative diseases characterized by accumulation of misfolded α-synuclein (α-syn) inclusions in neuronal and/or glial cells. Despite differences in the underlying pathophysiology, synucleinopathies often are misdiagnosed, especially in early stages, due to the overlapping clinical symptoms [1].

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Title
Translational Neurodegeneration
DOI
https://doi.org/10.1186/s40035-023-00346-0

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Published Here
July 22, 2024