2002 Articles
Imaging hippocampal function across the human life span: Is memory decline normal or not?
Memory function commonly declines in later life. Whether memory decline represents a disease process or whether it is part of normal aging remains unknown. Here we answer this question by assessing the function of multiple subregions that make up the hippocampal circuit across the human life span. A newly developed MRI approach—designed to detect functional changes in individual hippocampal subregions—was used to assess the hippocampal circuit in 70 subjects between 20 and 88 years of age. Using strict parametric criteria, analysis revealed that function in two hippocampal subregions—the subiculum and the dentate gyrus—decline normally with age. In contrast, function in the entorhinal cortex declines pathologically. Single-subject analysis revealed that hippocampal dysfunction, found in 60% of elders was selectively correlated with memory decline. These results show that memory decline is caused by different mechanisms and suggests how memory decline should be approached clinically.
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- Small et al. - 2002 - Imaging hippocampal function across the human life.pdf application/pdf 166 KB Download File
Also Published In
- Title
- Annals of Neurology
- DOI
- https://doi.org/10.1002/ana.10105
More About This Work
- Academic Units
- Neurology
- Published Here
- February 11, 2022