2023 Articles
Durability of Vaccine-Induced and Natural Immunity Against COVID-19: A Narrative Review
Vaccines developed against SARS-CoV-2 have proven to be highly effective in preventing symptomatic infection. Similarly, prior infection with SARS-CoV-2 has been shown to provide substantial protection against reinfection. However, it has become apparent that the protection provided to an individual after either vaccination or infection wanes over time. Waning protection is driven by both waning immunity over time since vaccination or initial infection, and the evolution of new variants of SARS-CoV-2. Both antibody and T/B-cells levels have been investigated as potential correlates of protection post-vaccination or post-infection. The activity of antibodies and T/B-cells provide some potential insight into the underlying causes of waning protection. This review seeks to summarise what is currently known about the waning of protection provided by both vaccination and/or prior infection, as well as the current information on the respective antibody and T/B-cell responses.
Files
- 40121_2022_Article_753.pdf application/pdf 291 KB Download File
Also Published In
- Title
- Springer Healthcare
- DOI
- https://doi.org/10.1007/s40121-022-00753-2
More About This Work
- Published Here
- July 22, 2024
Related Items
Notes
SARS-CoV-2, Waning immunity, Breakthrough infection, Reinfection, Antibody levels, Cellular immunity