Articles

Moderation Of The Relationship Between Reward Expectancy And Prediction Error-related Ventral Striatal Reactivity By Anhedonia In Unmedicated Major Depressive Disorder: Findings From The Embarc Study

Greenberg, Tsafrir; Chase, Henry W.; Almeida, Jorge R.; Stiffler, Richelle; Zevallos, Carlos R.; Aslam, Haris A.; Deckersbach, Thilo; Weyandt, Sarah; Cooper, Crystal; Toups, Marisa; Carmody, Thomas; Kurian, Benji; Peltier, Scott; Adams, Phillip; McInnis, Melvin G.; Oquendo, Maria A.; McGrath, Patrick J.; Fava, Maurizio; Weissman, Myrna M.; Parsey, Ramin; Trivedi, Madhukar H.; Phillips, Mary L.

Objective—Anhedonia, disrupted reward processing, is a core symptom of major depressive disorder. Recent findings demonstrate altered reward-related ventral striatal reactivity in depressed individuals, but the extent to which this is specific to anhedonia remains poorly understood. The authors examined the effect of anhedonia on reward expectancy (expected outcome value) and prediction error-(discrepancy between expected and actual outcome) related ventral striatal reactivity, as well as the relationship between these measures.

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Also Published In

Title
American Journal of Psychiatry
DOI
https://doi.org/10.1176/appi.ajp.2015.14050594

More About This Work

Academic Units
Epidemiology
Psychiatry
Published Here
February 1, 2022