Articles

Genetic Variants Within The Serotonin Transporter Associated With Familial Risk For Major Depression

Talati, Ardesheer; Guffanti, Guia; Odgerel, Zagaa; Ionita-Laza, Iuliana; Malm, Heli; Sourander, Andre; Brown, Alan S.; Wickramaratne, Priya J.; Gingrich, Jay A.; Weissman, Myrna M.

The role of the serotonin transporter promoter linked polymorphism (5HTTLPR) in depression, despite much research, remains unclear. Most studies compare persons with and without depression to each other. We show offspring at high (N¼ 192) as compared to low (N ¼101) familial risk for major depressive disorder were almost four times as likely to have two copies of the short allele at 5HTTLPR, suggesting that incorporation of family history could be helpful in identifying genetic differences.

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Also Published In

Title
Psychiatry Research
DOI
https://doi.org/10.1016/j.psychres.2015.04.015

More About This Work

Academic Units
Epidemiology
Psychiatry
Published Here
February 1, 2022