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Fractal Dimension Analysis of Subcortical Gray Matter Structures in Schizophrenia

Guihu Zhao; Kristina Denisova; Pejman Sehatpour; Jun Long; Weihua Gui; Jianping Qiao; Daniel C. Javitt; Zhishun Wang

Title:
Fractal Dimension Analysis of Subcortical Gray Matter Structures in Schizophrenia
Author(s):
Zhao, Guihu
Denisova, Kristina
Sehatpour, Pejman
Long, Jun
Gui, Weihua
Qiao, Jianping
Javitt, Daniel C.
Wang, Zhishun
Date:
Type:
Articles
Department(s):
Psychiatry
Volume:
11
Persistent URL:
Book/Journal Title:
PLoS ONE
Abstract:
A failure of adaptive inference—misinterpreting available sensory information for appropriate perception and action—is at the heart of clinical manifestations of schizophrenia, implicating key subcortical structures in the brain including the hippocampus. We used high resolution, three-dimensional (3D) fractal geometry analysis to study subtle and potentially biologically relevant structural alterations (in the geometry of protrusions, gyri and indentations, sulci) in subcortical gray matter (GM) in patients with schizophrenia relative to healthy individuals. In particular, we focus on utilizing Fractal Dimension (FD), a compact shape descriptor that can be computed using inputs with irregular (i.e., not necessarily smooth) surfaces in order to quantify complexity (of geometrical properties and configurations of structures across spatial scales) of subcortical GM in this disorder. Probabilistic (entropy-based) information FD was computed based on the box-counting approach for each of the seven subcortical structures, bilaterally, as well as the brainstem from high-resolution magnetic resonance (MR) images in chronic patients with schizophrenia (n = 19) and age matched healthy controls (n = 19) (age ranges: patients, 22.7–54.3 and healthy controls, 24.9–51.6 years old). We found a significant reduction of FD in the left hippocampus (median: 2.1460, range: 2.07–2.18 vs. median: 2.1730, range: 2.15–2.23, p<0.001; Cohen’s effect size, U3 = 0.8158 (95% Confidence Intervals, CIs: 0.6316, 1.0)), the right hippocampus (median: 2.1430, range: 2.05–2.19 vs. median: 2.1760, range: 2.12–2.21, p = 0.004; U3 = 0.8421 (CIs: 0.5263, 1)), as well as left thalamus (median: 2.4230, range: 2.40–2.44, p = 0.005; U3 = 0.7895 (CIs: 0.5789, 0.9473)) in schizophrenia patients, relative to healthy individuals. Our findings provide in-vivo quantitative evidence for reduced surface complexity of hippocampus, with reduced FD indicating a less complex, less regular GM surface detected in schizophrenia.
Subject(s):
Schizophrenia
Periaqueductal gray matter
Hippocampus (Brain)
Psychiatry
Developmental neurobiology
Publisher DOI:
https://doi.org/10.1371/journal.pone.0155415
Item views
39
Metadata:
text | xml
Suggested Citation:
Guihu Zhao, Kristina Denisova, Pejman Sehatpour, Jun Long, Weihua Gui, Jianping Qiao, Daniel C. Javitt, Zhishun Wang, , Fractal Dimension Analysis of Subcortical Gray Matter Structures in Schizophrenia, Columbia University Academic Commons, .

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