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Effectiveness of bystander naloxone administration and overdose education programs: a meta-analysis

Rebecca E. Giglio; Guohua Li; Charles J. DiMaggio

Title:
Effectiveness of bystander naloxone administration and overdose education programs: a meta-analysis
Author(s):
Giglio, Rebecca E.
Li, Guohua
DiMaggio, Charles J.
Date:
Type:
Articles
Department(s):
Epidemiology
Anesthesiology
Volume:
2
Persistent URL:
Book/Journal Title:
Injury Epidemiology
Publisher:
Springer
Abstract:
The objective of this review was to assess the effectiveness of bystander naloxone administration and overdose education programs by synthesizing quantitative results reported in the research literature. Studies meeting predefined criteria were identified and reviewed, and their results were synthesized through meta-analysis. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for overdose recoveries for individuals who received naloxone dispensed by non-medical community members, and the standardized mean difference was calculated for test scores of non-medical volunteers who received training in overdose management versus the scores of untrained volunteers. Pooled data from four studies showed that naloxone administration by bystanders was associated with a significantly increased odds of recovery compared with no naloxone administration (OR = 8.58, 95% CI = 3.90 to 13.25). Data from five studies of overdose education indicated that average scores were significantly higher for trained participants than untrained participants for tests on naloxone administration, overdose recognition, and overdose response (standardized mean difference = 1.35, 95% CI = 0.92 to 1.77). Empirical evidence in the research literature suggests that bystander naloxone administration and overdose education programs are associated with increased odds of recovery and with improved knowledge of overdose recognition and management in non-clinical settings.
Subject(s):
Naloxone
Opioid abuse
Drugs--Overdose
Public health
Epidemiology
Publisher DOI:
https://doi.org/10.1186/s40621-015-0041-8
Item views
179
Metadata:
text | xml
Suggested Citation:
Rebecca E. Giglio, Guohua Li, Charles J. DiMaggio, , Effectiveness of bystander naloxone administration and overdose education programs: a meta-analysis, Columbia University Academic Commons, .

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