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Levels of acute phase proteins remain stable after ischemic stroke

Mitchell S. Elkind; Kristen Coates; Wanling Tai; Myunghee Paik; Bernadette Boden-Albala; Ralph L. Sacco

Title:
Levels of acute phase proteins remain stable after ischemic stroke
Author(s):
Elkind, Mitchell S.
Coates, Kristen
Tai, Wanling
Paik, Myunghee
Boden-Albala, Bernadette
Sacco, Ralph L.
Date:
Type:
Articles
Department(s):
Neurology
Biostatistics
Sociomedical Sciences
Epidemiology
Volume:
6
Persistent URL:
Book/Journal Title:
BMC Neurology
Abstract:
Background: Inflammation and inflammatory biomarkers play an important role in atherosclerosis and cardiovascular disease. Little information is available, however, on time course of serum markers of inflammation after stroke. Methods: First ischemic stroke patients ≥40 years old had levels of high-sensitivity C-reactive protein (hsCRP), serum amyloid A (SAA), and fibrinogen measured in plasma samples drawn at 1, 2, 3, 7, 14, 21 and 28 days after stroke. Levels were log-transformed as needed, and parametric and non-parametric statistical tests were used to test for evidence of a trend in levels over time. Levels of hsCRP and SAA were also compared with levels in a comparable population of stroke-free participants. Results: Mean age of participants with repeated measures (n = 21) was 65.6 ± 11.6 years, and 13 (61.9%) were men, and 15 (71.4%) were Hispanic. Approximately 75% of patients (n = 15) had mild strokes (NIH Stroke Scale score 0–5). There was no evidence of a time trend in levels of hsCRP, SAA, or fibrinogen for any of the markers during the 28 days of follow-up. Mean log(hsCRP) was 1.67 ± 1.07 mg/L (median hsCRP 6.48 mg/L) among stroke participants and 1.00 ± 1.18 mg/L (median 2.82 mg/L) in a group of 1176 randomly selected stroke-free participants from the same community (p = 0.0252). Conclusion: Levels of hsCRP are higher in stroke patients than in stroke-free subjects. Levels of inflammatory biomarkers associated with atherosclerosis, including hsCRP, appear to be stable for at least 28 days after first ischemic stroke.
Subject(s):
C-reactive protein
Atherosclerosis--Etiology
Brain damage--Etiology
Cerebral ischemia--Pathophysiology
Neurosciences
Publisher DOI:
https://doi.org/10.1186/1471-2377-6-37
Item views
66
Metadata:
text | xml
Suggested Citation:
Mitchell S. Elkind, Kristen Coates, Wanling Tai, Myunghee Paik, Bernadette Boden-Albala, Ralph L. Sacco, , Levels of acute phase proteins remain stable after ischemic stroke, Columbia University Academic Commons, .

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