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From DNA to proteins via the ribosome: Structural insights into the workings of the translation machinery

Joachim Frank; Xabier Agirrezabala

Title:
From DNA to proteins via the ribosome: Structural insights into the workings of the translation machinery
Author(s):
Frank, Joachim
Agirrezabala, Xabier
Date:
Type:
Articles
Department(s):
Biochemistry and Molecular Biophysics
Volume:
4
Persistent URL:
Book/Journal Title:
Human Genomics
Publisher:
BioMed Central
Abstract:
Understanding protein synthesis in bacteria and humans is important for understanding the origin of many human diseases and devising treatments for them. Over the past decade, the field of structural biology has made significant advances in the visualisation of the molecular machinery involved in protein synthesis. It is now possible to discern, at least in outline, the way that interlocking ribosomal components and factors adapt their conformations throughout this process. The determination of structures in various functional contexts, along with the application of kinetic and fluorescent resonance energy transfer approaches to the problem, has given researchers the frame of reference for what remains as the greatest challenge: the complete dynamic portrait of protein synthesis in the cell.
Subject(s):
Genetics
Molecular biology
Item views
74
Metadata:
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Suggested Citation:
Joachim Frank, Xabier Agirrezabala, , From DNA to proteins via the ribosome: Structural insights into the workings of the translation machinery, Columbia University Academic Commons, .

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