Cohen Matthew A. author Columbia University. Obstetrics and Gynecology Lindheim Steven R. author Columbia University. Obstetrics and Gynecology Sauer Mark V. author Columbia University. Obstetrics and Gynecology Columbia University. Obstetrics and Gynecology originator text Articles 1999 English Hydrosalpinges have been associated with poor in-vitro fertilization (IVF) outcome in some, but not all, studies, perhaps through endometrial effects. To determine whether hydrosalpinges affect IVF outcome via endometrial factors alone, we analysed the results of recipients of donor oocytes with hydrosalpinges, thereby controlling for confounding variables, while isolating the intrauterine environment. We retrospectively analysed 110 patients who underwent 121 donor oocyte cycles in a university-based assisted reproduction programme. Thirteen cycles involving recipients (n = 10) with hydrosalpinges were compared to 108 cycles involving recipients (n = 100) without hydrosalpinges. Pregnancy, implantation, miscarriage, and ectopic pregnancy rates were compared between women with and without hydrosalpinges. There were no significant differences between the hydrosalpinx and no hydrosalpinx groups with respect to donor age, recipient age, or number or grade of embryos transferred. Patients with a hydrosalpinx had significantly lower embryo implantation rates (7.1 versus 19.3%, P < 0.05) and significantly higher miscarriage (75.0 versus 14.9%, P < 0.05) and ectopic pregnancy rates (33.3 versus 0.0%, P < 0.05) than normal controls. We conclude that the presence of a hydrosalpinx adversely affects early pregnancy events by altering the intrauterine environment. Genetics 14 4 1087 1089 1999-04 http://dx.doi.org/10.1093/humrep/14.4.1087 http://hdl.handle.net/10022/AC:P:14418 NNC NNC 2012-08-16 16:40:30 -0400 2012-08-16 16:52:20 -0400 8438 eng