Santhanam Anand P. author Imielinska Celina Z. author Columbia University. Radiation Oncology Davenport Paul author Kupelian Patrick author Rolland Jannick P. author Columbia University. Radiation Oncology originator text Articles 2008 English In this paper, we propose a physics-based and physiology-based approach for modeling real-time deformations of 3-D high-resolution polygonal lung models obtained from high-resolution computed tomography (HRCT) images of normal human subjects. The physics-based deformation operator is nonsymmetric, which accounts for the heterogeneous elastic properties of the lung tissue and spatial-dynamic flow properties of the air. An iterative approach is used to estimate the deformation with the deformation operator initialized based on the regional alveolar expandability, a key physiology-based parameter. The force applied on each surface node is based on the airflow pattern inside the lungs, which is known to be based on the orientation of the human subject. The validation of lung dynamics is done by resimulating the lung deformation and comparing it with HRCT data and computing force applied on each node derived from a 4-D HRCT dataset of a normal human subject using the proposed deformation operator and verifying its gradient with the orientation. Medical imaging and radiology 12 2 257 270 2008-03 http://dx.doi.org/10.1109/TITB.2007.899489 http://hdl.handle.net/10022/AC:P:14352 NNC NNC 2012-08-13 12:47:14 -0400 2012-08-13 12:54:30 -0400 8371 eng